Glucose Testing Variability and
the Need for an Expert Oversight Committee
CAP
Today, May 2005, Feature Story,
Joyce G.
Schwartz, MD, Samuel B. Reichberg, MD, PhD,
Raymond S. Gambino, MD
In 1979 a work group of the National Diabetes
Data Group1
established the criteria, later endorsed by the World Health
Organization Committee on Diabetes, that patients with a fasting
or 2-h postprandial glucose concentration greater than 140 or 200
mg/dL, respectively, were to be considered diabetic.
In 1997, the Expert Committee on the Diagnosis
and Classification of Diabetes Mellitus was convened to reexamine
the classification and diagnostic criteria for diabetes based on
the 1979 publication of the National Diabetes Data Group. As a
result of its deliberations, the committee recommended several
changes to the diagnostic criteria for diabetes and for lesser
degrees of impaired glucose regulation.2
The use of a fasting plasma glucose, or FPG, test for the
diagnosis of diabetes was recommended, and the cut point
separating diabetes from nondiabetes was lowered from a FPG >
140 mg/dL to > 126 mg/dL. This change was based on data
that showed an increase in prevalence and incidence of diabetic
retinopathy beginning approximately at a FPG of 126 mg/dL, as well
as on the desire to reduce the discrepancy that existed in the
number of cases detected by the FPG cut point of > 140 mg/dL
and the 2-h value in the OGTT (2-h plasma glucose) of > 200
mg/dL.
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